Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819615 | 0.98 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL11092732 | 0.93 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL5841179 | 0.87 | PLAU (0.48) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL3079261 | 0.87 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL7820909 | 0.84 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL3070239 | 0.82 | L3MBTL1 (0.65) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL3062573 | 0.82 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL3073425 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL15380727 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL19612360 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107753-A1 | MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5HT2 RECEPTORS | Advanced Medicine, Inc. (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-1999063996-A1 | MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5HT2 RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |