Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896210 | 0.81 | HTR1A (0.55) | HTR1ADRD2DRD3 | |
| SCHEMBL6363122 | 0.81 | HTR1A (0.55) | HTR1ADRD2DRD3 | |
| SCHEMBL9676278 | 0.81 | HTR1A (0.51) | HTR1ADRD2DRD3 | |
| SCHEMBL9676122 | 0.81 | HTR1A (0.51) | HTR1ADRD2DRD3 | |
| SCHEMBL7904426 | 0.80 | HTR1A (0.47) | HTR1ADRD2DRD3 | |
| SCHEMBL9676250 | 0.80 | HTR1A (0.47) | HTR1ADRD2DRD3 | |
| SCHEMBL7896171 | 0.77 | HTR1A (0.52) | HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7908041 | 0.77 | HTR1A (0.48) | HTR1ADRD2DRD3 | |
| SCHEMBL7905521 | 0.76 | HTR1A (0.48) | HTR1ADRD2DRD3 | |
| SCHEMBL9127389 | 0.71 | DRD2 (0.72) | HTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1275582-A | — | — | None | — | — | JP | disclosed |
| US-6201119-B1 | 2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-9-AMINE COMPOUNDS USEFUL AS INTERMEDIATES TO ANTIVIRALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-03-13 | — | — | US | disclosed |
| US-5371079-A | Administering to inhibit replication of HIV-1 in human cells | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-06 | — | — | US | disclosed |
| US-5270464-A | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-14 | — | — | US | disclosed |
| JP-H01275582-A | TETRAHYDROIMIDAZO(1,4)BENZODIAZEPIN-2-ONE COMPOUND | JANSSEN PHARMACEUT NV | 1989-11-06 | — | — | JP | disclosed |