Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.46 |
| ▸ | C5AR1 | P21730 | 9/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786060 | 0.93 | C5AR1 (0.50) | C5AR1LMNAOPRM1SIGMAR1TSHR | |
| SCHEMBL5211245 | 0.80 | HRH3 (0.45) | C5AR1OPRM1SIGMAR1GRIN2B | |
| SCHEMBL30942895 | 0.80 | C5AR1 (0.41) | C5AR1LMNAOPRM1SIGMAR1TSHR | |
| SCHEMBL2596501 | 0.79 | C5AR1 (0.52) | C5AR1LMNATSHRGRIN2B | |
| SCHEMBL2544909 | 0.79 | C5AR1 (0.52) | C5AR1LMNATSHRGRIN2B | |
| SCHEMBL11246158 | 0.78 | SLC18A3 (0.47) | C5AR1LMNAOPRM1TSHRSLC18A3 | |
| SCHEMBL11241533 | 0.78 | SLC18A3 (0.47) | C5AR1LMNAOPRM1TSHRSLC18A3 | |
| SCHEMBL11246162 | 0.78 | SLC18A3 (0.47) | C5AR1LMNAOPRM1TSHRSLC18A3 | |
| SCHEMBL6356355 | 0.76 | SIGMAR1 (0.49) | C5AR1LMNASIGMAR1 | |
| SCHEMBL803680 | 0.76 | C5AR1 (0.56) | C5AR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221402-B1 | CORE COMPRISING A MIXTURE OF A DRUG, LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, MICROCRYSTALLINE CELLULOSE AND BEING COATED WITH A WATER SOLUBLE POLYMER OVERCOATED WITH A SALIVA-INSOLUBLE POLYMER | PFIZER INC. | 2001-04-24 | — | — | US | disclosed |
| US-6211219-B1 | DRUGS, ANALGESICS AND AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2001-04-03 | — | — | US | disclosed |