Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | DCK | P27707 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7905959 | 0.99 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4ENOTUMCHEK2HDAC1 | |
| SCHEMBL7905739 | 0.95 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4ENOTUMHDAC1HDAC2 | |
| SCHEMBL7905953 | 0.89 | RAB9A (0.45) | SMN1; SMN2KDM4ELSSHRH3CXCR1 | |
| SCHEMBL7903925 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4ENOTUMHDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL7908541 | 0.89 | RAB9A (0.44) | SMN1; SMN2KDM4ELSSHRH3CXCR1 | |
| SCHEMBL7896538 | 0.84 | RAB9A (0.43) | SMN1; SMN2KDM4ETNK2HRH3ADORA2A | |
| SCHEMBL7896441 | 0.82 | HTR1B (0.37) | KDM4ELSSHRH3 | |
| Hydrochloric Acid SCHEMBL7903914 | 0.81 | HTR1B (0.36) | KDM4ELSSHRH3 | |
| SCHEMBL7896418 | 0.77 | RAB9A (0.46) | SMN1; SMN2KDM4EHDAC1HDAC2HDAC6 | |
| SCHEMBL7905806 | 0.77 | HTR7 (0.40) | SMN1; SMN2KDM4EADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | claimed |
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | disclosed |
| EP-0958294-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS GYOGYSZERGYAR (HU) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030561-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS Gyógyszergyár Rt. (HU) | 1998-07-16 | — | — | WO | disclosed |