Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8925164 | 0.88 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7911026 | 0.85 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7900831 | 0.83 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7319448 | 0.77 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7042502 | 0.76 | PDE4A (0.76) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7907751 | 0.75 | PDE4D (0.76) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8572806 | 0.75 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7907749 | 0.73 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4818633 | 0.72 | PDE4A (0.72) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6231315 | 0.71 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |
| US-5622977-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |