SCHEMBL7909000

SCHEMBL7909000

CCCCOc1cc(OCc2ccccc2)ccc1C(=O)O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.58
PTPN11 Q06124 1/20 0.52
MCL1 Q07820 2/20 0.52
NR4A2 P43354 2/20 0.51
NR4A1 P22736 1/20 0.51
NR4A3 Q92570 1/20 0.51
ALDH1A1 P00352 2/20 0.51
CYP3A4 P08684 1/20 0.51
TSHR P16473 1/20 0.51
MAPK1 P28482 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
LTB4R Q15722 1/20 0.51
LTB4R2 Q9NPC1 1/20 0.51
SLC16A3 O15427 1/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
HPGD P15428 1/20 0.49
MDH2 P40926 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22438599 0.94 PTPN11 (0.55) MAOBPTPN11MCL1ALDH1A1CYP3A4
SCHEMBL9324047 0.93 PTPN11 (0.58) MAOBPTPN11TSHR
SCHEMBL21924233 0.91 MAOB (0.60) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL22438896 0.91 PTPN11 (0.62) MAOBPTPN11MCL1TSHR
SCHEMBL22438999 0.91 PTPN11 (0.62) MAOBPTPN11MCL1TSHR
SCHEMBL6042635 0.89 MEN1 (0.57) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL7908047 0.89 MAOB (0.55) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL4756552 0.88 MAOB (0.63) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL7908442 0.87 MAOB (0.56) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL21924280 0.87 ALDH1A1 (0.60) MAOBMCL1NR4A2NR4A1NR4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211234-B1 BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID RHONE-POULENC RORER LIMITED (GB) 2001-04-03 US disclosed
EP-0728128-B1 SUBSTITUTED PHENYL COMPOUNDS RHONE POULENC RORER LTD (GB) 1998-09-16 EP disclosed
EP-0728128-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1996-08-28 EP disclosed
WO-1995013262-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1995-05-18 WO disclosed