Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.65 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.65 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.65 |
| ▸ | TNIK | Q9UKE5 | 12/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3761935 | 0.86 | CLK1 (0.65) | CLK1DYRK1ADYRK2DYRK1BTNIK | |
| SCHEMBL7908973 | 0.84 | CLK1 (0.66) | CLK1DYRK1ADYRK2DYRK1BTNIK | |
| SCHEMBL7907491 | 0.83 | AXL (0.64) | TNIKNTRK1MAP3K11 | |
| SCHEMBL7905041 | 0.82 | NTRK1 (0.63) | CLK1DYRK1ADYRK2DYRK1BTNIK | |
| SCHEMBL7906551 | 0.82 | KIT (0.57) | CLK1DYRK1ADYRK2DYRK1BTNIK | |
| SCHEMBL7910407 | 0.81 | MAP3K11 (0.47) | CLK1DYRK1ADYRK2DYRK1BTNIK | |
| SCHEMBL12067516 | 0.80 | TNIK (0.61) | TNIKNTRK1MAP4K1MAP3K11 | |
| SCHEMBL8941800 | 0.80 | CLK1 (0.81) | CLK1DYRK1ADYRK2DYRK1BTNIK | |
| SCHEMBL7908989 | 0.79 | MAP3K11 (0.63) | CLK1DYRK1ADYRK2DYRK1BTNIK | |
| SCHEMBL7912925 | 0.79 | MAP3K11 (0.51) | TNIKNTRK1MAP4K1MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |