Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | CLK1 | P49759 | 2/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906551 | 0.90 | KIT (0.57) | MAP3K11LRRK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7905041 | 0.90 | NTRK1 (0.63) | MAP3K11CYP3A4CYP2D6NTRK1KIT | |
| SCHEMBL7907491 | 0.86 | AXL (0.64) | MAP3K11NTRK1KITAXLCDK8 | |
| SCHEMBL7910407 | 0.86 | MAP3K11 (0.47) | MAP3K11NTRK1KITDYRK1ACLK1 | |
| SCHEMBL7906025 | 0.84 | MAP3K11 (0.69) | MAP3K11NTRK1KITDYRK1ACLK1 | |
| SCHEMBL7910174 | 0.84 | MAP3K11 (0.60) | MAP3K11KITDYRK1APIK3CA | |
| SCHEMBL7899036 | 0.83 | KIT (0.63) | MAP3K11LRRK2NTRK1KITDYRK1A | |
| SCHEMBL12068189 | 0.81 | DYRK1A (0.56) | MAP3K11NTRK1PDPK1KITDYRK1A | |
| SCHEMBL7906295 | 0.81 | MAP4K1 (0.66) | MAP3K11NTRK1DYRK1ACLK1DYRK2 | |
| SCHEMBL7903775 | 0.81 | KIT (0.73) | KITDYRK1APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |