Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.64 |
| ▸ | CDK8 | P49336 | 3/20 | 0.64 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.64 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.57 |
| ▸ | SGK1 | O00141 | 4/20 | 0.56 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905041 | 0.90 | NTRK1 (0.63) | AXLCDK8TNIKKITMAP3K11 | |
| SCHEMBL7906551 | 0.87 | KIT (0.57) | AXLCDK8TNIKKITMAP3K11 | |
| SCHEMBL7908989 | 0.86 | MAP3K11 (0.63) | AXLCDK8TNIKKITMAP3K11 | |
| SCHEMBL7910407 | 0.85 | MAP3K11 (0.47) | AXLCDK8TNIKKITMAP3K11 | |
| SCHEMBL26177531 | 0.85 | PARP10 (0.62) | AXLCDK8TNIKKITMAP3K11 | |
| SCHEMBL7912925 | 0.84 | MAP3K11 (0.51) | TNIKMAP3K11SGK1NTRK1 | |
| SCHEMBL7906025 | 0.84 | MAP3K11 (0.69) | AXLCDK8TNIKKITMAP3K11 | |
| SCHEMBL7910174 | 0.84 | MAP3K11 (0.60) | KITMAP3K11 | |
| SCHEMBL12068189 | 0.83 | DYRK1A (0.56) | AXLCDK8TNIKKITMAP3K11 | |
| SCHEMBL7909336 | 0.83 | CLK1 (0.65) | TNIKMAP3K11NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |