Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12479521 | 0.91 | SMN1; SMN2 (0.53) | HTR2CSMN1; SMN2CYP2C19PREPRAB9A | |
| Hydrochloric Acid SCHEMBL1532877 | 0.90 | SMN1; SMN2 (0.52) | HTR2CSMN1; SMN2CYP2C19PREPRAB9A | |
| SCHEMBL8220722 | 0.89 | HTR2C (0.53) | HTR2CSMN1; SMN2CYP2C19PREPRAB9A | |
| SCHEMBL7251746 | 0.89 | HTR2C (0.53) | HTR2CSMN1; SMN2CYP2C19PREPRAB9A | |
| SCHEMBL4674934 | 0.88 | HTR2C (0.52) | HTR2CSMN1; SMN2CYP2C19PREPRAB9A | |
| SCHEMBL28978066 | 0.85 | HTR2C (0.50) | HTR2CSMN1; SMN2CYP2C19PREPRAB9A | |
| SCHEMBL3017853 | 0.84 | HTR2C (0.52) | HTR2CSMN1; SMN2PREPRAB9ANPC1 | |
| SCHEMBL6487292 | 0.84 | HTR2C (0.52) | HTR2CSMN1; SMN2PREPRAB9ANPC1 | |
| SCHEMBL6501753 | 0.84 | HTR2C (0.52) | HTR2CSMN1; SMN2PREPRAB9ANPC1 | |
| SCHEMBL21854732 | 0.83 | HTR2C (0.51) | HTR2CSMN1; SMN2PREPRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |