Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F13A1 | P00488 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | TGM1 | P22735 | 1/20 | 0.44 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900109 | 0.92 | MAPT (0.49) | F13A1TGM2TGM1TGM3ST14 | |
| SCHEMBL8382214 | 0.89 | F13A1 (0.47) | F13A1TGM2TGM1TGM3ST14 | |
| SCHEMBL8381979 | 0.87 | MAPT (0.48) | F13A1TGM2TGM1TGM3NAMPT | |
| SCHEMBL8381166 | 0.87 | F13A1 (0.49) | F13A1TGM2TGM1TGM3ST14 | |
| SCHEMBL9339092 | 0.84 | HTT (0.46) | F13A1TGM2TGM1TGM3ST14 | |
| SCHEMBL8385674 | 0.84 | GLA (0.52) | F13A1TGM2TGM1TGM3RAB9A | |
| SCHEMBL7906634 | 0.83 | MEN1 (0.49) | NAMPTRAB9AMAPTEPHX2MEN1 | |
| SCHEMBL7909711 | 0.83 | ST14 (0.40) | F13A1TGM2TGM1TGM3ST14 | |
| SCHEMBL7907921 | 0.82 | ST14 (0.46) | F13A1TGM2TGM1TGM3ST14 | |
| Hydrochloric Acid SCHEMBL7909852 | 0.81 | POLB (0.51) | GAANAMPTRAB9AMAPTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |