Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL222920 | 0.79 | PREP (0.53) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| SCHEMBL1601359 | 0.73 | USP2 (0.42) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| SCHEMBL1838102 | 0.71 | PREP (0.37) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| SCHEMBL173435 | 0.71 | USP2 (0.49) | USP2SMN1; SMN2PREPESR2HPGD | |
| SCHEMBL1242684 | 0.71 | USP2 (0.52) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| SCHEMBL2496477 | 0.71 | USP2 (0.52) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| Hydrochloric Acid SCHEMBL28241841 | 0.70 | PREP (0.36) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| SCHEMBL2600436 | 0.70 | USP2 (0.40) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| SCHEMBL28856336 | 0.70 | CHRM2 (0.38) | USP2SMN1; SMN2PREPESR2NR1H2 | |
| SCHEMBL4693378 | 0.69 | HPGD (0.46) | USP2SMN1; SMN2PREPESR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211184-B1 | TETRAHYDRO-PYRAZINE OR PYRIMIDINE DERIVATIVES; VITRONECTIN RECEPTOR ANTAGONIST; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTITUMOR AGENTS; ANGIOGENESIS AND RESTENOSIS INHIBITORS | MERCK & CO., INC. | 2001-04-03 | — | — | US | disclosed |
| US-5981546-A | Integrin antagonists | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | disclosed |