Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 10/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | UGCG | Q16739 | 3/20 | 0.40 |
| ▸ | MGAM | O43451 | 2/20 | 0.40 |
| ▸ | SI | P14410 | 2/20 | 0.40 |
| ▸ | AGL | P35573 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GLB1 | P16278 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19159501 | 0.85 | GBA2 (0.37) | GBA2GAAUGCGMGAMSI | |
| SCHEMBL11532970 | 0.85 | SIGMAR1 (0.39) | GBA2GAAUGCGMGAMSI | |
| SCHEMBL24135089 | 0.84 | S1PR1 (0.38) | GBA2GAAGBA1S1PR1S1PR3 | |
| SCHEMBL25059014 | 0.82 | S1PR1 (0.41) | GBA2GAAGBA1S1PR1S1PR3 | |
| SCHEMBL27979603 | 0.79 | — | — | |
| SCHEMBL11530769 | 0.79 | — | — | |
| SCHEMBL11571899 | 0.77 | — | — | |
| SCHEMBL21778432 | 0.74 | GBA2 (0.44) | GBA2GAAUGCGGBA1SIGMAR1 | |
| SCHEMBL7023481 | 0.74 | S1PR1 (0.60) | GBA2S1PR1S1PR3S1PR5 | |
| Fluoride SCHEMBL29252575 | 0.73 | S1PR1 (0.59) | GBA2S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1145619-C | 1-4-benzothiazepine-1,1-dioxide derivatives substituted by sugar radicals, methods for the production thereof, medicaments containing these compounds and the use thereof | ���ĵ�˹ҩ��¹�����˾ | 2004-04-14 | — | — | CN | disclosed |
| CN-1346352-A | 1, 4-benzothiazepine-1, 1-dioxide derivatives substituted by sugar radicals, method for the production thereof, medicaments containing these compounds and the use thereof | AVENTIS PHARMA GMBH (DE) | 2002-04-24 | — | — | CN | disclosed |
| US-6277831-B1 | TREATMENT OF HYPERLIPIDEMIA, ARTERIOSCLEROSIS HYPERCHOLESTEROLEMIA; HYPOLIPIDEMIC ACTION; HIGHER EXCRETION OF BILE ACID EVEN AT A LOWER DOSAGE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-08-21 | — | — | US | disclosed |