Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 5/20 | 0.64 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.64 |
| ▸ | SHBG | P04278 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909915 | 1.00 | SRD5A1 (0.64) | SRD5A1SRD5A2SHBG | |
| SCHEMBL9486929 | 1.00 | SRD5A1 (0.64) | SRD5A1SRD5A2SHBG | |
| SCHEMBL8651905 | 0.86 | SRD5A1 (0.54) | SRD5A1SRD5A2SHBG | |
| SCHEMBL8651900 | 0.86 | SRD5A1 (0.54) | SRD5A1SRD5A2SHBG | |
| SCHEMBL8722381 | 0.85 | SRD5A1 (0.61) | SRD5A1SRD5A2 | |
| SCHEMBL8722379 | 0.85 | SRD5A1 (0.61) | SRD5A1SRD5A2 | |
| SCHEMBL8023852 | 0.85 | SRD5A1 (0.58) | SRD5A1SRD5A2 | |
| SCHEMBL8023848 | 0.85 | SRD5A1 (0.58) | SRD5A1SRD5A2 | |
| SCHEMBL5070240 | 0.85 | SRD5A1 (0.67) | SRD5A1SRD5A2 | |
| SCHEMBL5070238 | 0.85 | SRD5A1 (0.67) | SRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778284-A2 | New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | claimed |
| EP-0572166-A1 | New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors | MERCK & CO. INC. (US) | 1993-12-01 | — | — | EP | claimed |
| US-6204273-B1 | TREATMENT OF ANDROGENIC SENSITIVE DISORDERS SUCH AS ACNE VULGARIS, SEBORRHEA, FEMALE HIRSUTISM, MALE PATTERN BALDNESS, AND BENIGN PROSTATIC HYPERPLASIA. | MERCK & CO., INC. | 2001-03-20 | — | — | US | disclosed |
| EP-0756481-B1 | 17$g(b)-ARYL-4-AZA-STEROID DERIVATIVES | MERCK & CO INC (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5910497-A | 16-pyrazinyl-substituted-4-aza-androstane 5-α-reductase isozyme 1 inhibitors | MERCK & CO., INC. (US) | 1999-06-08 | — | — | US | disclosed |
| EP-0786999-A4 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO INC (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0724592-B1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO INC (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0792371-A4 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO INC (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0756481-A4 | 17-g(b)-ARYL-4-AZA-STEROID DERIVATIVES | MERCK & CO INC (US) | 1998-11-18 | — | — | EP | disclosed |
| EP-0700291-B1 | 15-SUBSTITUTED 4-AZASTEROIDS | MERCK & CO INC (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0771203-A4 | METHOD OF TREATING SWEAT-RELATED CONDITIONS | MERCK & CO INC (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1996012487-A1 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO., INC. (US) | 1996-05-02 | — | — | WO | disclosed |
| EP-0700291-A1 | 15-SUBSTITUTED 4-AZASTEROIDS | MERCK & CO. INC. (US) | 1996-03-13 | — | — | EP | disclosed |
| WO-1996003129-A1 | METHOD OF TREATING SWEAT-RELATED CONDITIONS | MERCK & CO., INC. (US) | 1996-02-08 | — | — | WO | disclosed |
| WO-1995028928-A1 | 17β-ARYL-4-AZA-STEROID DERIVATIVES | MERCK & CO., INC. (US) | 1995-11-02 | — | — | WO | disclosed |
| WO-1995011254-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO., INC. (US) | 1995-04-27 | — | — | WO | disclosed |
| US-5359071-A | Selective antagonist of testosterone 5-alpha-reductase 1 | MERCK & CO., INC. (US) | 1994-10-25 | — | — | US | disclosed |
| WO-1994020104-A1 | 15-SUBSTITUTED 4-AZASTEROIDS | MERCK & CO, INC. (US) | 1994-09-15 | — | — | WO | disclosed |
| EP-0572166-A1 | New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors | MERCK & CO. INC. (US) | 1993-12-01 | — | — | EP | disclosed |
| WO-1993023420-A1 | NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | disclosed |