Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.51 |
| ▸ | ELANE | P08246 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021502 | 0.82 | NOTUM (0.59) | NOTUMELANEPOLBCYP1A2ALDH1A1 | |
| SCHEMBL7903085 | 0.79 | ELANE (0.66) | ELANE | |
| SCHEMBL5752612 | 0.78 | NOTUM (0.76) | NOTUMELANEPOLBCYP1A2GSR | |
| SCHEMBL29808797 | 0.78 | NOTUM (0.76) | NOTUMELANEPOLBCYP1A2GSR | |
| SCHEMBL8065166 | 0.76 | NOTUM (0.65) | NOTUMELANEPOLBCYP1A2GSR | |
| SCHEMBL984085 | 0.75 | NOTUM (0.64) | NOTUMELANEPOLBCYP1A2GSR | |
| SCHEMBL4152306 | 0.74 | NOTUM (0.62) | NOTUMELANEPOLBCYP1A2GSR | |
| SCHEMBL8063220 | 0.73 | NOTUM (0.61) | NOTUMELANEPOLBCYP1A2GSR | |
| SCHEMBL560810 | 0.73 | NOTUM (0.61) | NOTUMELANEPOLBCYP1A2GSR | |
| SCHEMBL8236829 | 0.72 | NOTUM (0.60) | NOTUMELANEPOLBCYP1A2ALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094964-A1 | TOSYLATE SALT OF A 5-PYRAZOLYL-2-PYRIDONE DERIVATIVE, USEFUL IN THE TREATMENT OF COPD | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | WO | disclosed |