Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31265285 | 0.75 | CYP1A2 (0.57) | — | |
| SCHEMBL2992524 | 0.74 | AHR (0.56) | AHRTSHRTP53CYP3A4CA12 | |
| SCHEMBL651464 | 0.72 | AHR (0.54) | AHR | |
| SCHEMBL651465 | 0.72 | AHR (0.54) | AHR | |
| SCHEMBL73815 | 0.72 | AHR (0.54) | AHRTSHRTP53CYP3A4CA12 | |
| SCHEMBL18851547 | 0.72 | AHR (0.54) | AHRTSHRTP53CYP3A4 | |
| SCHEMBL5046561 | 0.72 | AHR (0.48) | AHRTSHRTP53CYP3A4 | |
| SCHEMBL2088489 | 0.72 | AHR (0.48) | AHRTSHRCA12CA1CA2 | |
| SCHEMBL2088491 | 0.72 | AHR (0.48) | AHRTSHRCA12CA1CA2 | |
| SCHEMBL6460048 | 0.70 | AHR (1.00) | AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131401-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-23 | — | — | US | disclosed |
| US-20130131401-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-23 | — | — | US | disclosed |
| US-8378122-B2 | Process for the preparation of chymase modulators | JANSSEN PHARMACEUTICA NV. (BE) | 2013-02-19 | — | — | US | disclosed |
| US-8378122-B2 | Process for the preparation of chymase modulators | JANSSEN PHARMACEUTICA NV. (BE) | 2013-02-19 | — | — | US | disclosed |
| US-20120309986-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | ANZALONE LUIGI (US) | 2012-12-06 | — | — | US | disclosed |
| US-20120309986-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | ANZALONE LUIGI (US) | 2012-12-06 | — | — | US | disclosed |
| US-8263785-B2 | Process for the preparation of chymase modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-09-11 | — | — | US | disclosed |
| US-8263785-B2 | Process for the preparation of chymase modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-09-11 | — | — | US | disclosed |
| US-20100145075-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-06-10 | — | — | US | disclosed |
| US-20100145075-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-06-10 | — | — | US | disclosed |
| WO-2010051372-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131401-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | CMA1, SERPINB1, CPA3 | AHR 3512/4885TSHR 3552/4885TP53 4298/4885 |
| US-20120309986-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | CMA1, SERPINB1, CPA3 | AHR 3512/4885TSHR 3552/4885TP53 4298/4885 |
| US-20100145075-A1 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS | CMA1, SERPINB1, CPA3 | AHR 3512/4885TSHR 3552/4885TP53 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.