Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | POLB | P06746 | 2/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CFTR | P13569 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692188 | 0.87 | MAPT (0.61) | MAPTSMN1; SMN2POLBTDP1L3MBTL1 | |
| SCHEMBL7901219 | 0.87 | MAPT (0.59) | MAPTSMN1; SMN2POLBTDP1PTGDR2 | |
| SCHEMBL4682703 | 0.86 | MAPT (0.79) | MAPTSMN1; SMN2POLBTDP1L3MBTL1 | |
| SCHEMBL14144797 | 0.84 | SMN1; SMN2 (0.81) | MAPTSMN1; SMN2POLBTDP1L3MBTL1 | |
| SCHEMBL4682094 | 0.83 | SMN1; SMN2 (0.79) | MAPTSMN1; SMN2POLBTDP1L3MBTL1 | |
| SCHEMBL8543208 | 0.78 | GABRA1 (0.51) | MAPTSMN1; SMN2POLBTDP1PTGDR2 | |
| SCHEMBL6335193 | 0.78 | SMN1; SMN2 (0.79) | MAPTSMN1; SMN2POLBTDP1L3MBTL1 | |
| SCHEMBL4006702 | 0.78 | SMN1; SMN2 (0.74) | MAPTSMN1; SMN2POLBTDP1L3MBTL1 | |
| SCHEMBL4682039 | 0.76 | MAPT (0.76) | MAPTSMN1; SMN2POLBTDP1L3MBTL1 | |
| SCHEMBL4688360 | 0.76 | MCL1 (0.56) | SMN1; SMN2POLBL3MBTL1RAB9AGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |