Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | MARS1 | P56192 | 3/20 | 0.52 |
| ▸ | GRN | P28799 | 2/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7910944 | 0.87 | MAPT (0.80) | MAPTSMN1; SMN2POLBTDP1MCL1 | |
| SCHEMBL27687138 | 0.86 | SMN1; SMN2 (0.69) | MAPTSMN1; SMN2POLBTDP1MARS1 | |
| SCHEMBL4688360 | 0.84 | MCL1 (0.56) | SMN1; SMN2POLBMCL1GABRA1GABRB2 | |
| SCHEMBL8543208 | 0.83 | GABRA1 (0.51) | MAPTSMN1; SMN2POLBTDP1MCL1 | |
| SCHEMBL27687135 | 0.83 | MARS1 (0.65) | MAPTSMN1; SMN2POLBTDP1MARS1 | |
| SCHEMBL8889722 | 0.81 | MAPT (0.70) | MAPTSMN1; SMN2POLBTDP1MARS1 | |
| SCHEMBL8589911 | 0.81 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2POLBTDP1MARS1 | |
| SCHEMBL4689814 | 0.79 | GRN (0.64) | MAPTSMN1; SMN2POLBTDP1MARS1 | |
| SCHEMBL2828470 | 0.76 | FFAR1 (0.62) | MDM2 | |
| SCHEMBL2830042 | 0.75 | FFAR1 (0.61) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | claimed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | claimed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | claimed |
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |