Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.53 |
| ▸ | PDE4A | P27815 | 12/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27657387 | 0.83 | PDE4A (0.56) | PDE4DPDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL28062431 | 0.82 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8461881 | 0.81 | PDE4A (0.79) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL6882017 | 0.79 | PDE4A (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7782679 | 0.77 | PDE4A (0.56) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL5309884 | 0.76 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL8206531 | 0.76 | PDE4A (0.80) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL8483493 | 0.75 | PDE4A (0.65) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8793521 | 0.74 | PDE4A (0.60) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7911022 | 0.74 | PDE4A (0.85) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |