Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.80 |
| ▸ | FPR2 | P25090 | 2/20 | 0.55 |
| ▸ | PDE5A | O76074 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435711 | 0.89 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7448547 | 0.89 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7406024 | 0.89 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL8461881 | 0.89 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8465957 | 0.87 | PDE4D (0.75) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL5309884 | 0.86 | PDE4D (0.67) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL12560338 | 0.84 | ERN1 (0.63) | PDE4APDE4DPDE4BPDE4CPOLB | |
| SCHEMBL8465685 | 0.82 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL7782679 | 0.82 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL8769586 | 0.82 | PDE4B (0.58) | PDE4APDE4DPDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745063-B1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PROD (US) | 1999-03-24 | — | — | EP | claimed |
| US-5691376-A | ANTIHISTAMINE, ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-25 | — | — | US | claimed |
| US-6080790-A | SELECTIVE AND POTENT INHIBITORS OF PHOSPHODIESTERASE IV AND ARE USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY DISEASES AND THE ALLEVIATION OF CONDITIONS ASSOCIATED WITH CENTRAL NERVOUS MALFUNCTION | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0745063-B1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PROD (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0618889-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1998-12-30 | — | — | EP | disclosed |
| US-5691376-A | ANTIHISTAMINE, ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-25 | — | — | US | disclosed |
| US-5674880-A | ANTIINFLAMMATORY AGENT | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-07 | — | — | US | disclosed |
| US-5650444-A | BRONCHODILATOR AGENTS, ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-07-22 | — | — | US | disclosed |
| US-5491147-A | PHOSPHODIESTERASE IV INHIBITORS | CELLTECH, LIMITED (GB) | 1996-02-13 | — | — | US | disclosed |