Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 4/20 | 0.35 |
| ▸ | RXRB | P28702 | 3/20 | 0.35 |
| ▸ | RXRG | P48443 | 2/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912845 | 0.72 | HTT (0.45) | HTT | |
| SCHEMBL7913005 | 0.72 | HTT (0.45) | HTT | |
| SCHEMBL927089 | 0.71 | ALDH1A1 (0.49) | NR4A1NR4A2NR4A3RXRARXRB | |
| SCHEMBL12329635 | 0.69 | CYP19A1 (0.44) | NR4A2RXRARXRBRXRG | |
| SCHEMBL13267207 | 0.68 | RXRA (0.48) | NR4A2RXRARXRBRXRG | |
| SCHEMBL3002325 | 0.67 | ACACB (0.45) | NR4A1NR4A2NR4A3RXRARXRB | |
| SCHEMBL1750107 | 0.66 | KMT2A (0.47) | NR4A1NR4A2NR4A3RXRARXRB | |
| SCHEMBL1749785 | 0.66 | KMT2A (0.51) | NR4A1NR4A2NR4A3RXRARXRB | |
| SCHEMBL12868793 | 0.66 | RXRA (0.44) | NR4A2RXRARXRBRXRGAGTR2 | |
| SCHEMBL14456050 | 0.66 | RXRA (0.44) | NR4A2RXRARXRBRXRGAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211212-B1 | DRUGS WITH AMIDE AND ESTER GROUPS AS ENZYME INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0970062-A2 | PYRROLIDINE AND THIAZOLE DERIVATIVES WITH METALLO-BETA-LACTAMASE INHIBITORY PROPERTIES | SMITHKLINE BEECHAM PLC (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998040056-A2 | PYRROLIDINE AND THIAZOLE DERIVATIVES WITH METALLO-BETA-LACTAMASE INHIBITORY PROPERTIES | SMITHKLINE BEECHAM PLC (GB) | 1998-09-17 | — | — | WO | disclosed |