Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | LSS | P48449 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113122 | 0.89 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2POLBPKMSGMS1 | |
| SCHEMBL9272868 | 0.86 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2POLBLSSSGMS1 | |
| SCHEMBL7877042 | 0.84 | PDE4A (0.65) | ALDH1A1SMN1; SMN2POLBLSSCA12 | |
| SCHEMBL15619063 | 0.83 | ALDH1A1 (0.88) | ALDH1A1SMN1; SMN2POLBPKMCA12 | |
| SCHEMBL11335294 | 0.83 | ALDH1A1 (0.88) | ALDH1A1SMN1; SMN2POLBPKMSGMS1 | |
| SCHEMBL10523408 | 0.82 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2POLBPKMSGMS1 | |
| SCHEMBL10462588 | 0.82 | LSS (0.67) | ALDH1A1SMN1; SMN2LSSCYP19A1CA12 | |
| SCHEMBL29259796 | 0.82 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2POLBPKMSGMS1 | |
| SCHEMBL6799293 | 0.82 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2POLBPKMSGMS1 | |
| SCHEMBL5188475 | 0.82 | ALDH1A1 (0.81) | ALDH1A1SMN1; SMN2POLBPKMSGMS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6215001-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS, AND ANTIALLERGENS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 2001-04-10 | — | — | US | disclosed |
| US-6031109-A | Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-02-29 | — | — | US | disclosed |
| US-5780642-A | NON-STEROIDAL ANTIINFLAMMATORY AGENT WHICH BLOCKS RELEASE OF ARACHIDONIC ACID FROM PHOSPHOLIPIDS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| WO-1995000493-A1 | IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |