SCHEMBL7911534

SCHEMBL7911534

COC(=O)CCCCC(=O)CC(=O)OC(C)C

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.53
TSHR P16473 4/20 0.52
ALDH1A1 P00352 1/20 0.43
EPHX2 P34913 4/20 0.41
KDM4E B2RXH2 1/20 0.38
RECQL P46063 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PGR P06401 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
ADRA2C P18825 1/20 0.37
SLC6A2 P23975 1/20 0.37
HTR2B P41595 1/20 0.37
MC3R P41968 1/20 0.37
SLC6A3 Q01959 1/20 0.37
PDE4D Q08499 1/20 0.37
SCN5A Q14524 1/20 0.37
HSD17B10 Q99714 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13800475 0.86 LMNA (0.70) LMNATSHRALDH1A1EPHX2RECQL
SCHEMBL18074008 0.85 LMNA (0.69) LMNATSHRALDH1A1PGRADORA3
SCHEMBL29467308 0.85 LMNA (0.69) LMNATSHRALDH1A1PGRADORA3
SCHEMBL9068448 0.84 TSHR (0.47) LMNATSHRALDH1A1EPHX2L3MBTL1
SCHEMBL3266395 0.83 TSHR (0.67) LMNATSHRALDH1A1EPHX2KDM4E
SCHEMBL29467310 0.82 LMNA (0.60) LMNATSHRALDH1A1KDM4EPGR
SCHEMBL25175789 0.81 LMNA (0.69) LMNATSHRALDH1A1EPHX2PGR
SCHEMBL8196189 0.81 TSHR (0.64) LMNATSHRALDH1A1EPHX2KDM4E
SCHEMBL16012498 0.80 TSHR (0.42) LMNATSHRALDH1A1EPHX2L3MBTL1
SCHEMBL16012441 0.80 TSHR (0.42) LMNATSHRALDH1A1EPHX2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0863125-B1 Process for the preparation of enantiomerically pure diesters of 3-hydroxyoctandioic acid by asymmetric catalytic hydrogenation ASTA MEDICA AG (DE) 2001-11-28 EP disclosed
US-6229042-B1 INTERMEDIATES FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE ALPHA-LIPOIC ACID; SAID HYDROGENATION INCLUDES PRESENCE OF RUTHENIUM-PHOSPHINE COMPLEX ASTA MEDICA AKTIENGESELLSCHAFT (DE) 2001-05-08 US disclosed
US-6013833-A USING A CATALYST OF A COMPLEX OF RUTHENIUM AND AN OPTICALLY ACTIVE PHOSPHINE; PRODUCING (R)-3-HYDROXYOCTANEDIOIC ACID DIESTERS AS CHEMICAL INTERMEDIATES OF ALPHA-LIPOIC ACID ASTA MEDICA AKTIENGESELLSCHAFT (DE) 2000-01-11 US disclosed
EP-0863125-A1 Process for the preparation of enantiomerically pure diesters of 3-hydroxyoctandioic acid by asymmetric catalytic hydrogenation ASTA Medica Aktiengesellschaft (DE) 1998-09-09 EP disclosed
US-5530143-A REDUCTION OF (3S)-3-HYDROXYOCTANEDIOIC DIESTER WITH COMPLEX HYDRIDE BASF AKTIENGESELLSCHAFT (DE) 1996-06-25 US disclosed