Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965973 | 0.89 | CYP3A4 (0.49) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL31139332 | 0.87 | PDK1 (0.58) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL29991279 | 0.87 | MAPT (0.54) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL1985668 | 0.87 | MAPT (0.54) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL8711740 | 0.87 | AURKA (0.50) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL1858721 | 0.87 | PDK1 (0.58) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL29969056 | 0.85 | AURKA (0.52) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL30632213 | 0.85 | AURKA (0.49) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL1865895 | 0.85 | AURKA (0.49) | AURKARPS6KB1SIRT2HDAC3HDAC1 | |
| SCHEMBL16246277 | 0.85 | AURKA (0.49) | AURKARPS6KB1SIRT2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |
| US-6291485-B1 | TREATMENT OF POST-PTCA RESTENOSIS | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| CN-1262681-A | 4,5-dihydro-[1H]-benz [g] indazole-3-carboxylic acid derivatives | TEIKOKU HORMONE MFG CO LTD (JP) | 2000-08-09 | — | — | CN | disclosed |
| EP-1002797-A1 | 4,5-DIHYDRO- 1H]-BENZ g]INDAZOLE-3-CARBOXYLIC ACID DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2000-05-24 | — | — | EP | disclosed |