SCHEMBL1985668

SCHEMBL1985668

CCc1cccc(NC(=O)OC(C)(C)C)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.54
SMN1; SMN2 Q16637 5/20 0.53
HDAC3 O15379 3/20 0.52
HDAC1 Q13547 3/20 0.52
HDAC2 Q92769 3/20 0.52
HDAC8 Q9BY41 3/20 0.52
HDAC6 Q9UBN7 3/20 0.52
HDAC4 P56524 2/20 0.52
HDAC7 Q8WUI4 2/20 0.52
HDAC10 Q969S8 2/20 0.52
HDAC11 Q96DB2 2/20 0.52
HDAC9 Q9UKV0 2/20 0.52
HDAC5 Q9UQL6 2/20 0.52
HPGD P15428 1/20 0.52
MAPK1 P28482 1/20 0.52
KMT2A Q03164 3/20 0.50
MEN1 O00255 2/20 0.50
RAB9A P51151 2/20 0.50
GAA P10253 2/20 0.50
TAS1R3 Q7RTX0 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29991279 1.00 MAPT (0.54) MAPTSMN1; SMN2HDAC3HDAC1HDAC2
SCHEMBL13801959 0.88 CYP3A4 (0.50) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL31139332 0.88 PDK1 (0.58) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL8711740 0.88 AURKA (0.50) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL1858721 0.88 PDK1 (0.58) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL1865895 0.87 AURKA (0.49) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL7911540 0.87 AURKA (0.49) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL16246277 0.87 AURKA (0.49) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL30632213 0.87 AURKA (0.49) HDAC3HDAC1HDAC2HDAC8HDAC6
SCHEMBL29969056 0.87 AURKA (0.52) HDAC3HDAC1HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240068009-A1 SUBSTITUTED IMIDAZO[1,2-a]PYRAZINES AS LUCIFERASE SUBSTRATES PROMEGA CORPORATION 2024-02-29 US disclosed
US-11781168-B2 Process for preparing substituted imidazo[1,2-α]pyrazines PROMEGA CORPORATION (US) 2023-10-10 US disclosed
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF TXINNO BIOSCIENCE INC. (KR) 2023-05-25 US disclosed
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF TXINNO BIOSCIENCE INC. (KR) 2023-05-25 US disclosed
WO-2021225407-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE INHIBITORY ACTIVITY, AND USE THEREOF 주식회사 티씨노바이오사이언스 (KR) 2021-11-11 WO disclosed
US-10669568-B2 Substituted imidazo[1,2-a]pyrazines as luciferase substrates PROMEGA CORPORATION (US) 2020-06-02 US disclosed
US-20200115356-A1 Modulation of Bacterial Quorum Sensing With Synthetic Ligands WISCONSIN ALUMNI RESEARCH FOUNDATION 2020-04-16 US disclosed
WO-2019174601-A1 HETEROARYL COMPOUNDS AS KINASE INHIBITOR FUJIAN HAIXI PHARMACEUTICALS CO., LTD (CN) 2019-09-19 WO disclosed
US-20190241932-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2019-08-08 US disclosed
US-10294237-B2 Bicyclic heterocyclic amide derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2019-05-21 US disclosed
US-20170233789-A1 COELENTERAZINE ANALOGUES JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2017-08-17 US disclosed
CN-104311486-A 2-oxo-1,2-dihydro-quinoline modulators of immune function TEVA PHARMA 2015-01-28 CN disclosed
US-20120184541-A1 COMPOUNDS AND METHODS OF USE ABBVIE INC. 2012-07-19 US disclosed
US-8114893-B2 Compounds and methods of use GENENTECH, INC. (US) 2012-02-14 US disclosed
CN-102143949-A 2-carbonyl-1, 2-dihydroquinoline modulators of immune function TEVA PHARMA 2011-08-03 CN disclosed
EP-2337779-A2 2-OXO-1,2-DIHYDRO-QUINOLINE MODULATORS OF IMMUNE FUNCTION Teva Pharmaceutical Industries Ltd. (IL) 2011-06-29 EP disclosed
US-7935699-B2 Pyrazole glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2011-05-03 US disclosed
WO-2010028015-A2 2-OXO-1,2-DIHYDRO-QUINOLINE MODULATORS OF IMMUNE FUNCTION AUSPEX PHARMACEUTICALS, INC (US) 2010-03-11 WO disclosed
US-20080021032-A1 Pyrazole glucokinase activators BERTHEL STEVEN JOSEPH 2008-01-24 US disclosed
WO-2007044449-A2 NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS SCHERING CORPORATION (US) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11781168-B2 Process for preparing substituted imidazo[1,2-α]pyrazines CYP4Z1, CYP2E1, CYP2F1 MAPT 2877/4885SMN1; SMN2 2626/4885HDAC3 1408/4885
US-20200115356-A1 Modulation of Bacterial Quorum Sensing With Synthetic Ligands AHCYL1, EBPL, AIP MAPT 4822/4885SMN1; SMN2 4883/4885HDAC3 2709/4885
US-10294237-B2 Bicyclic heterocyclic amide derivative NR0B1, NR2E1, NR0B2 MAPT 4815/4885SMN1; SMN2 3595/4885HDAC3 71/4885
US-20190241932-A1 COELENTERAZINE ANALOGUES GLB1, SI, TCF7L2 MAPT 4859/4885SMN1; SMN2 3970/4885HDAC3 446/4885
US-20170233789-A1 COELENTERAZINE ANALOGUES GLB1, SI, TCF7L2 MAPT 4859/4885SMN1; SMN2 3970/4885HDAC3 446/4885
US-20240068009-A1 SUBSTITUTED IMIDAZO[1,2-a]PYRAZINES AS LUCIFERASE SUBSTRATES PGLS, AADAC, GLB1 MAPT 4849/4885SMN1; SMN2 4438/4885HDAC3 922/4885
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF ENPP1, ENPP3, PPA1 MAPT 2828/4885SMN1; SMN2 3741/4885HDAC3 1770/4885
US-20120184541-A1 COMPOUNDS AND METHODS OF USE BCL2A1, BCL2, BAX MAPT 4858/4885SMN1; SMN2 1830/4885HDAC3 3283/4885
US-20080021032-A1 Pyrazole glucokinase activators GCKR, GCK, GALK1 MAPT 3888/4885SMN1; SMN2 4412/4885HDAC3 958/4885
US-10669568-B2 Substituted imidazo[1,2-a]pyrazines as luciferase substrates AADAC, PGLS, GLB1 MAPT 4847/4885SMN1; SMN2 4453/4885HDAC3 880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.