Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904992 | 0.88 | PLA2G1B (0.60) | ALDH1A1HPGDL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL27570670 | 0.83 | PLA2G1B (0.65) | ALDH1A1POLBTDP1SMN1; SMN2GAA | |
| SCHEMBL25314971 | 0.82 | HPGD (0.56) | ALDH1A1HPGDL3MBTL1CTDSP1POLB | |
| SCHEMBL7898884 | 0.81 | NR1H3 (0.54) | ALDH1A1HPGDL3MBTL1CTDSP1POLB | |
| SCHEMBL8586537 | 0.78 | CA9 (0.55) | ALDH1A1HPGDL3MBTL1CTDSP1POLB | |
| SCHEMBL1618305 | 0.78 | ALDH1A1 (0.70) | ALDH1A1HPGDL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL7898829 | 0.78 | PLA2G1B (0.59) | ALDH1A1HPGDL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL11246411 | 0.77 | POLB (0.77) | ALDH1A1CTDSP1POLBTDP1MAPT | |
| SCHEMBL2339850 | 0.76 | TSHR (0.61) | ALDH1A1HPGDL3MBTL1POLBTDP1 | |
| SCHEMBL7898827 | 0.76 | NR1H3 (0.60) | ALDH1A1POLBMAPTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083888-A1 | MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063983-A9 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999063983-A1 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |