Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.42 |
| ▸ | ITGAL | P20701 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908676 | 1.00 | MAPT (0.43) | MAPTHTTMEN1KMT2ALMNA | |
| SCHEMBL3851420 | 0.86 | TSHR (0.50) | MAPTHTTMEN1KMT2ALMNA | |
| SCHEMBL3816016 | 0.86 | TSHR (0.50) | MAPTHTTMEN1KMT2ALMNA | |
| SCHEMBL7907136 | 0.86 | ERCC5 (0.49) | MAPTHTTMEN1KMT2ALMNA | |
| SCHEMBL7908710 | 0.86 | ERCC5 (0.49) | MAPTHTTMEN1KMT2ALMNA | |
| SCHEMBL7799493 | 0.83 | PLOD2 (0.51) | MAPTHTTMEN1KMT2ALMNA | |
| SCHEMBL7799498 | 0.83 | PLOD2 (0.51) | MAPTHTTMEN1KMT2ALMNA | |
| SCHEMBL7908375 | 0.83 | CES2 (0.40) | MAPTKDM4EITGB2ICAM1ITGAL | |
| SCHEMBL7899386 | 0.83 | CES2 (0.40) | MAPTKDM4EITGB2ICAM1ITGAL | |
| SCHEMBL7908401 | 0.83 | CES2 (0.40) | MAPTKDM4EITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931056-A1 | N-SUBSTITUTED-2-AMINO-4-PHENYL-4-OXO-BUTANOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITORY ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-07-28 | — | — | EP | claimed |
| WO-1998009938-A1 | N-SUBSTITUTED-2-AMINO-4-PHENYL-4-OXO-BUTANOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITORY ACTIVITY | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-03-12 | — | — | WO | claimed |
| US-6207709-B1 | FOR THERAPY AND PROPHYLAXIS OF NEURODEGENERATIVE DISEASES, SUCH AS HUNTINGTON'S CHOREA, ALZHEIMER'S DISEASE, DEMENTIA CAUSED BY AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFARCTUAL DEMENTIA, CEREBRAL ISCHEMIA, CEREBRAL HYPOXIA, EPILEPSY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-03-27 | — | — | US | disclosed |