Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 7/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800347 | 0.91 | MAPT (0.40) | MAPTKMT2ATHRBAKR1C3TP53 | |
| SCHEMBL7803258 | 0.88 | MAPT (0.39) | MAPTKMT2ATHRBAKR1C3TP53 | |
| SCHEMBL7784773 | 0.85 | MAPT (0.36) | MAPTKMT2ATHRBAKR1C3TP53 | |
| SCHEMBL7938698 | 0.84 | KMT2A (0.35) | MAPTKMT2ATHRBAKR1C3TP53 | |
| SCHEMBL7787500 | 0.79 | MAPT (0.40) | MAPTKMT2ATHRBAKR1C3TP53 | |
| SCHEMBL6035985 | 0.79 | MAPT (0.49) | MAPTKMT2AAKR1C3ALDH1A1 | |
| SCHEMBL6035984 | 0.79 | NPC1 (0.53) | MAPTKMT2AAKR1C3SMN1; SMN2PTGS2 | |
| SCHEMBL7932216 | 0.77 | AKR1C3 (0.31) | AKR1C3 | |
| SCHEMBL7743790 | 0.76 | TBXA2R (0.48) | MAPTKMT2ATBXA2RSLC6A2SLC6A4 | |
| SCHEMBL6036004 | 0.76 | ALDH1A1 (0.54) | MAPTKMT2ATHRBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140046-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035435-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |