SCHEMBL7912562

SCHEMBL7912562

C=C[C@H]1CC[C@H](c2ccc(CCc3ccc([C@H]4CC[C@H](CCCF)CC4)cc3)cc2)CC1

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 3/20 0.38
SPHK1 Q9NYA1 12/20 0.37
CYP2C9 P11712 2/20 0.33
ESR1 P03372 1/20 0.33
CYP3A4 P08684 1/20 0.33
SPHK2 Q9NRA0 7/20 0.33
ALOX5 P09917 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7912569 1.00 ESR2 (0.38) ESR2SPHK1CYP2C9ESR1CYP3A4
SCHEMBL15043588 0.88 SPHK1 (0.43) SPHK1CYP3A4SPHK2
SCHEMBL9552299 0.85 SPHK1 (0.45) ESR2SPHK1CYP2C9ESR1CYP3A4
SCHEMBL9552303 0.85 SPHK1 (0.45) ESR2SPHK1CYP2C9ESR1CYP3A4
SCHEMBL7910109 0.85 ESR2 (0.37) ESR2CYP2C9ESR1CYP3A4
SCHEMBL7910103 0.85 ESR2 (0.37) ESR2CYP2C9ESR1CYP3A4
SCHEMBL8853239 0.84 SPHK1 (0.40) SPHK1CYP3A4SPHK2
SCHEMBL2384580 0.84 SPHK1 (0.47) ESR2SPHK1CYP2C9SPHK2
SCHEMBL7912583 0.83 SPHK1 (0.36) ESR2SPHK1SPHK2
SCHEMBL7912579 0.83 SPHK1 (0.36) ESR2SPHK1SPHK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6174456-B1 STABILITY, LOW VISCOSITY AND HIGH TRANSITION TEMPERATURE OF THE ISOTROPIC PHASE CHISSO CORPORATION (JP) 2001-01-16 US disclosed
EP-0857708-A1 LIQUID CRYSTAL COMPOUNDS HAVING SUBSTITUTED ALKYL GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT CHISSO CORPORATION (JP) 1998-08-12 EP disclosed