Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.34 |
| ▸ | TPH1 | P17752 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913108 | 0.87 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| SCHEMBL7916724 | 0.85 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| SCHEMBL7913009 | 0.85 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| SCHEMBL7903016 | 0.83 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| SCHEMBL7916798 | 0.83 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| SCHEMBL7912936 | 0.82 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| Dimethylamine SCHEMBL7911323 | 0.81 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| SCHEMBL7916814 | 0.81 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| SCHEMBL7902795 | 0.81 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CMAPTALDH1A1 | |
| SCHEMBL7902819 | 0.80 | ALDH1A1 (0.38) | MAPTALDH1A1NPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258829-B1 | ANTIARRTHMIA AGENTS AND CARDIOVASCULAR DISORDERS | TOA EIYO LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0972767-A1 | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME | TOA EIYO LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |