SCHEMBL7913292

SCHEMBL7913292

CC12CC3CC(N)(CCCC3(C)C1)C2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.42
GRIN1 Q05586 2/20 0.42
GRIN2A Q12879 2/20 0.42
SLC22A1 O15245 1/20 0.42
GRIN2D O15399 1/20 0.42
GRIN3B O60391 1/20 0.42
ESR1 P03372 1/20 0.42
ADRB3 P13945 1/20 0.42
ACHE P22303 1/20 0.42
OPRK1 P41145 1/20 0.42
MTOR P42345 1/20 0.42
HTT P42858 1/20 0.42
GRIN2B Q13224 1/20 0.42
GRIN2C Q14957 1/20 0.42
GRIN3A Q8TCU5 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
NFKB1 P19838 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21548130 0.81 LMNA (0.52) LMNAGRIN1GRIN2ASLC22A1GRIN2D
SCHEMBL14385368 0.75 LMNA (0.35) LMNAGRIN1GRIN2ASLC22A1GRIN2D
SCHEMBL14385021 0.74 LMNA (0.41) LMNAGRIN1GRIN2ASLC22A1GRIN2D
SCHEMBL14385290 0.73 LMNA (0.39) LMNAGRIN1GRIN2ASLC22A1GRIN2D
SCHEMBL21298754 0.73
SCHEMBL7922215 0.72
SCHEMBL7928095 0.72
SCHEMBL8227711 0.72
SCHEMBL13699365 0.69 GRIN2D (0.33) GRIN1GRIN2AGRIN2DGRIN3BGRIN2B
SCHEMBL3671265 0.68 LMNA (0.38) LMNAGRIN1GRIN2ASLC22A1GRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010083996-A1 A PROCESS FOR PREPARING MEMANTINE MERZ PHARMA GMBH & CO. KGAA (DE) 2010-07-29 WO disclosed
WO-2010015415-A1 PROCESS FOR MANUFACTURING ADAMANTANE DERIVATIVES WITH HIGH YIELD MERZ PHARMA GMBH & CO. KGAA (DE) 2010-02-11 WO disclosed
WO-2009115334-A2 PROCESS FOR THE MANUFACTURE OF MEMANTINE AND INTERMEDIATE PRODUCT MERZ PHARMA GMBH & CO. KGAA (DE) 2009-09-24 WO disclosed
WO-2008063847-A2 METHOD FOR TREATING AUTISM FOREST LABORATORIES HOLDINGS LIMITED (BM) 2008-05-29 WO disclosed
EP-1886670-A1 Pharmaceutical compositions of memantine Teva Pharmaceutical Industries Ltd (IL) 2008-02-13 EP disclosed
WO-2007132476-A2 A PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE MATRIX LABORATORIES LIMITED (IN) 2007-11-22 WO disclosed
WO-2007096124-A1 PROCESS FOR THE PREPARATION OF ADAMANTANAMINES HEXAL AG (DE) 2007-08-30 WO disclosed
WO-2005070429-A1 PHARMACEUTICAL COMPOSITION COMPRISING A MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR AND AN N-METHYL-D-ASPARTATE (NMDA) RECEPTORS ANTAGONIST NEUROSEARCH A/S (DK) 2005-08-04 WO disclosed