Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27045013 | 0.78 | GRIN1 (0.46) | LMNAGRIN1GRIN2ASLC22A1GRIN2D | |
| SCHEMBL21298754 | 0.73 | — | — | |
| SCHEMBL18972626 | 0.69 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL25973603 | 0.69 | LMNA (0.35) | LMNAGRIN1GRIN2ASLC22A1GRIN2D | |
| SCHEMBL9951831 | 0.69 | LMNA (0.36) | LMNAGRIN1GRIN2ASLC22A1GRIN2D | |
| SCHEMBL7913292 | 0.68 | LMNA (0.42) | LMNAGRIN1GRIN2ASLC22A1GRIN2D | |
| SCHEMBL19221390 | 0.66 | LMNA (0.33) | LMNAGRIN1GRIN2ASLC22A1GRIN2D | |
| SCHEMBL19084050 | 0.65 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL24970382 | 0.64 | GRIN1 (0.46) | LMNAGRIN1GRIN2ASLC22A1GRIN2D | |
| SCHEMBL18902409 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170806-A1 | ASSAY METHODS FOR MEMANTINE | Generics Ýuk¨Limited (GB) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009010806-A1 | ASSAY METHODS FOR MEMANTINE | GENERICS [UK] LIMITED (GB) | 2009-01-22 | — | — | WO | disclosed |
| EP-1742624-A2 | DOPAMINE-AGONIST COMBINATION THERAPY WITH SEDATIVES FOR IMPROVING SLEEP QUALITY | Sepracor, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005079851-A2 | DOPAMINE-AGONIST COMBINATION THERAPY WITH SEDATIVES FOR IMPROVING SLEEP QUALITY | SEPRACOR, INC. (US) | 2005-09-01 | — | — | WO | disclosed |