Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27470171 | 0.78 | ADORA2A (0.58) | LMNAADORA2AHSD17B10ADORA1HTT | |
| SCHEMBL6072033 | 0.74 | CDK5 (0.49) | LMNAADORA2AHSD17B10ADORA1HTT | |
| SCHEMBL6072337 | 0.74 | CDK5 (0.54) | LMNAADORA2AHSD17B10ADORA1HTT | |
| SCHEMBL28383673 | 0.73 | KDM4E (0.66) | LMNAADORA2AHSD17B10ADORA1HTT | |
| SCHEMBL6767155 | 0.73 | ADORA2A (0.58) | ADORA2AHSD17B10ADORA1HTTADRA2A | |
| SCHEMBL6072771 | 0.73 | ADORA2A (0.56) | LMNAADORA2AHSD17B10ADORA1HTT | |
| SCHEMBL7011406 | 0.72 | ADORA2A (0.70) | LMNAADORA2AHSD17B10ADORA1HTT | |
| SCHEMBL31636814 | 0.72 | POLB (0.56) | ADORA2AHSD17B10ADORA1HTTADRA2A | |
| SCHEMBL16618011 | 0.72 | LMNA (0.45) | LMNAKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL4436700 | 0.71 | ADORA2A (0.60) | LMNAADORA2AHSD17B10ADORA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297258-B1 | USEFUL AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE. | AMERICAN CYANAMID COMPANY | 2001-10-02 | — | — | US | disclosed |