Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913482 | 0.85 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4DSIGMAR1 | |
| SCHEMBL7919822 | 0.82 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7913480 | 0.81 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7914465 | 0.81 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DHIF1A | |
| SCHEMBL7916316 | 0.80 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSIGMAR1 | |
| SCHEMBL7916035 | 0.80 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7916410 | 0.80 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL6584431 | 0.80 | HIF1A (0.47) | HIF1AEPAS1HTR2CSIGMAR1SMN1; SMN2 | |
| SCHEMBL7906247 | 0.78 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL8310588 | 0.78 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |