Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903396 | 0.81 | ACE (0.39) | NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL7910773 | 0.81 | THRB (0.40) | NPC1ALDH1A1RAB9AFKBP1A | |
| SCHEMBL24113489 | 0.77 | EPHX1 (0.38) | EPHX1PREPPDE4BHSD17B10 | |
| SCHEMBL4308796 | 0.77 | EPHX1 (0.38) | EPHX1PREPPDE4BHSD17B10 | |
| SCHEMBL25764462 | 0.77 | EPHX1 (0.38) | EPHX1PREPPDE4BHSD17B10 | |
| SCHEMBL16943545 | 0.76 | PREP (0.37) | EPHX1PREPNPC1ALDH1A1HSD17B10 | |
| SCHEMBL16943564 | 0.76 | PREP (0.37) | EPHX1PREPNPC1ALDH1A1HSD17B10 | |
| SCHEMBL15247679 | 0.76 | PREP (0.38) | PREPHPGDHSD17B10 | |
| SCHEMBL16732850 | 0.75 | HSD17B10 (0.44) | EPHX1PREPHPGDGPR119HSD17B10 | |
| SCHEMBL5204643 | 0.75 | HSD17B10 (0.44) | EPHX1PREPHPGDGPR119HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214841-B1 | ANTICOAGULANTS | ELI LILLY AND COMPANY | 2001-04-10 | — | — | US | disclosed |
| EP-0884326-A2 | Antithrombitic compound | ELI LILLY AND COMPANY (US) | 1998-12-16 | — | — | EP | disclosed |
| EP-0670310-B1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | LILLY CO ELI (US) | 1998-09-02 | — | — | EP | disclosed |
| EP-0670310-A1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-09-06 | — | — | EP | disclosed |