Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27334025 | 0.83 | CYP3A4 (0.36) | THRBATML3MBTL1ALDH1A1GAA | |
| SCHEMBL27352660 | 0.82 | KMT2A (0.35) | L3MBTL1ALDH1A1GAAHTTKMT2A | |
| SCHEMBL7903396 | 0.81 | ACE (0.39) | ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL7913496 | 0.81 | EPHX1 (0.37) | ALDH1A1FKBP1ANPC1RAB9A | |
| SCHEMBL27438982 | 0.78 | FKBP1A (0.32) | FKBP1AGAAKMT2A | |
| SCHEMBL8292058 | 0.78 | DPP4 (0.32) | GAACHRM1KMT2AMAPT | |
| SCHEMBL3454065 | 0.72 | ALDH1A1 (0.42) | ALDH1A1HTTKMT2AMAPTPOLB | |
| SCHEMBL27524171 | 0.72 | GAA (0.36) | THRBATML3MBTL1ALDH1A1GAA | |
| SCHEMBL3574137 | 0.71 | MEN1 (0.37) | ALDH1A1FKBP1AGAAKMT2AMAPT | |
| SCHEMBL13078850 | 0.71 | MEN1 (0.37) | ALDH1A1FKBP1AGAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214841-B1 | ANTICOAGULANTS | ELI LILLY AND COMPANY | 2001-04-10 | — | — | US | disclosed |
| EP-0884326-A2 | Antithrombitic compound | ELI LILLY AND COMPANY (US) | 1998-12-16 | — | — | EP | disclosed |
| EP-0670310-B1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | LILLY CO ELI (US) | 1998-09-02 | — | — | EP | disclosed |
| EP-0670310-A1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-09-06 | — | — | EP | disclosed |