Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911822 | 1.00 | ENPP2 (0.43) | ENPP2MEN1KMT2AMAPTALOX15 | |
| SCHEMBL381475 | 0.90 | MEN1 (0.46) | MEN1KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL12731994 | 0.83 | MAPT (0.51) | MEN1KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL7386839 | 0.81 | MAPT (0.47) | MEN1KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL9395662 | 0.77 | MEN1 (0.68) | MEN1KMT2AMAPTALOX15NPC1 | |
| SCHEMBL8791993 | 0.77 | MEN1 (0.68) | MEN1KMT2AMAPTALOX15NPC1 | |
| SCHEMBL12731996 | 0.77 | MEN1 (0.38) | MEN1KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL6697450 | 0.77 | KCNH2 (0.38) | MEN1KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL14351707 | 0.76 | NPC1 (0.62) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL381302 | 0.76 | NPC1 (0.62) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214829-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2001-04-10 | — | — | US | disclosed |
| EP-0900792-A1 | Piperazine and piperidine derivatives as 5-HT1 receptor agonists | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1999-03-10 | — | — | EP | disclosed |