SCHEMBL7914136

SCHEMBL7914136

CC#CCOC(=O)C(O)c1ccccc1C1CCCCC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 2/20 0.40
MMP9 P14780 2/20 0.37
MMP1 P03956 1/20 0.37
MMP2 P08253 1/20 0.37
MMP12 P39900 1/20 0.37
MMP13 P45452 2/20 0.36
ADAM17 P78536 2/20 0.36
NAAA Q02083 1/20 0.35
CYP1A2 P05177 2/20 0.35
ADRA2A P08913 2/20 0.35
CYP2D6 P10635 2/20 0.35
CHRM1 P11229 2/20 0.35
CYP2C9 P11712 2/20 0.35
TBXA2R P21731 2/20 0.35
SLC6A2 P23975 2/20 0.35
ADRA1A P35348 2/20 0.35
OPRM1 P35372 2/20 0.35
DRD3 P35462 2/20 0.35
KCNH2 Q12809 2/20 0.35
USP2 O75604 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3364418 0.86 PTGDR2 (0.38) PTGDR2NAAACYP1A2ADRA2ACYP2D6
SCHEMBL7913181 0.86 ADRA2A (0.43) PTGDR2NAAACYP1A2ADRA2ACYP2D6
SCHEMBL3365274 0.84 CHRM2 (0.53) PTGDR2CYP1A2ADRA2ACYP2D6CHRM1
SCHEMBL8475476 0.84 PTGDR2 (0.36) PTGDR2NAAACYP1A2ADRA2ACYP2D6
SCHEMBL8578195 0.83 CYP3A4 (0.43) PTGDR2NAAACYP1A2ADRA2ACYP2D6
SCHEMBL290175 0.83 TSHR (0.45) PTGDR2NAAACYP1A2ADRA2ACYP2D6
SCHEMBL8473282 0.82 PTGDR2 (0.35) PTGDR2NAAACYP1A2ADRA2ACYP2D6
SCHEMBL25188997 0.82 SLC6A2 (0.43) PTGDR2CYP1A2ADRA2ACYP2D6CHRM1
SCHEMBL11467456 0.80 PTGDR2 (0.43) PTGDR2SLC6A2SLC6A4SLC6A3MEN1
SCHEMBL7905925 0.80 PTGDR2 (0.40) PTGDR2NAAACYP1A2ADRA2ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207852-B1 THERAPY FOR INCONTINENCE; CROHN'S DISEASE; MUSCLE RELAXANTS BRIDGE PHARMA, INC. 2001-03-27 US disclosed
EP-0915826-A4 SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF BRIDGE PHARMA INC (US) 1999-12-29 EP disclosed
EP-0915826-A1 SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF Bridge Pharma, Inc. (US) 1999-05-19 EP disclosed
WO-1998000390-A1 SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF BRIDGE PHARMA, INC. (US) 1998-01-08 WO disclosed