Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.53 |
| ▸ | PARP1 | P09874 | 5/20 | 0.52 |
| ▸ | AR | P10275 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918121 | 0.96 | LMNA (0.56) | LMNAHTTNPSR1PRMT5WDR77 | |
| SCHEMBL12955389 | 0.85 | AR (0.72) | LMNAPRMT5PARP1AR | |
| SCHEMBL16110564 | 0.85 | PRMT5 (0.53) | LMNAPRMT5WDR77PARP1AR | |
| SCHEMBL16110172 | 0.81 | PARP1 (0.53) | LMNAPRMT5WDR77PARP1AR | |
| SCHEMBL4697283 | 0.81 | PARP1 (0.53) | LMNAPRMT5WDR77PARP1AR | |
| SCHEMBL2526818 | 0.78 | PRMT5 (0.74) | PRMT5WDR77PARP1AR | |
| SCHEMBL2429268 | 0.77 | LMNA (0.70) | LMNAHTTNPSR1PRMT5WDR77 | |
| SCHEMBL12955388 | 0.76 | LMNA (0.72) | LMNAHTTNPSR1PARP1AR | |
| SCHEMBL7914610 | 0.76 | FLT1 (0.55) | NPSR1KMT2APKMOPRM1OPRD1 | |
| SCHEMBL4701154 | 0.76 | RAB9A (0.57) | LMNAHTTPARP1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218392-B1 | FOR THERAPY AND PROPHYLAXIS OF ISCHEMIC HEART DISEASES SUCH AS ANGINA PECTORIS, MYOCARDIAL INFARCT AND CHRONIC AND ACUTE CARDIAC FAILURE, PULMONARY HYPERTENSION, ARTERIOSCLEROSIS AND BRONCHIAL ASTHMA | EISAI CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| US-5849741-A | Fused pyridazine compounds | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0722936-A1 | FUSED PYRIDAZINE COMPOUND | Eisai Co., Ltd. (JP) | 1996-07-24 | — | — | EP | disclosed |