SCHEMBL7914911

SCHEMBL7914911

COc1ccc(OC)c(Nc2nnc(-c3ccc(OC)cc3OC)c3ccccc23)c1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.52
KMT2A Q03164 5/20 0.52
MAPT P10636 8/20 0.50
LMNA P02545 5/20 0.50
L3MBTL1 Q9Y468 3/20 0.50
SHMT2 P34897 3/20 0.50
GAA P10253 2/20 0.50
USP2 O75604 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50
TP53 P04637 1/20 0.49
TSHR P16473 1/20 0.49
ALDH1A1 P00352 3/20 0.48
HPGD P15428 3/20 0.48
MAPK1 P28482 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
NPC1 O15118 1/20 0.48
KDM4E B2RXH2 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7915131 0.92 SHMT2 (0.46) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL7904894 0.86 MAPT (0.62) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL7918610 0.86 MEN1 (0.56) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL7912186 0.86 MAPT (0.55) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL7904825 0.83 MAPT (0.63) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL7913390 0.82 MAPT (0.56) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL7905044 0.82 MAPT (0.55) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL7918683 0.81 KDR (0.60) MEN1KMT2AMAPTLMNATP53
SCHEMBL7904898 0.79 MAPT (0.59) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL7915149 0.79 MAPT (0.52) MEN1KMT2AMAPTLMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207666-B1 TREATING PRECANCEROUS LESIONS BY ADMINISTERING 4-PHENYLPHTHALAZINE DERIVATIVE CELL PATHWAYS, INC. 2001-03-27 US disclosed