Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.53 |
| ▸ | HTR2C | P28335 | 10/20 | 0.53 |
| ▸ | HTR2B | P41595 | 10/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2343214 | 1.00 | HTR2A (0.53) | HTR2AHTR2CHTR2BMTORPIK3R1 | |
| SCHEMBL2344858 | 0.84 | HTR2A (0.59) | HTR2AHTR2CHTR2B | |
| SCHEMBL2339465 | 0.84 | HTR2C (0.57) | HTR2AHTR2CHTR2B | |
| SCHEMBL2340827 | 0.83 | HTR2A (0.51) | HTR2AHTR2CHTR2BMTORPIK3R1 | |
| SCHEMBL2335257 | 0.83 | HTR2A (0.51) | HTR2AHTR2CHTR2BMTORPIK3R1 | |
| Hydrochloric Acid SCHEMBL2340784 | 0.83 | HTR2A (0.58) | HTR2AHTR2CHTR2B | |
| SCHEMBL2342805 | 0.82 | HTR2A (0.55) | HTR2AHTR2CHTR2BMTORPIK3R1 | |
| SCHEMBL2341762 | 0.81 | PIK3R1 (0.45) | MTORPIK3R1PIK3CA | |
| SCHEMBL7917057 | 0.78 | PIK3R1 (0.47) | MTORPIK3R1PIK3CA | |
| SCHEMBL7917278 | 0.78 | PIK3R1 (0.47) | MTORPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829011-B2 | 2-aminopyrimidine compounds as serotonin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-09 | — | — | US | disclosed |
| US-8829011-B2 | 2-aminopyrimidine compounds as serotonin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-09 | — | — | US | disclosed |
| US-20110207717-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-08-25 | — | — | US | disclosed |
| US-20110207717-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-08-25 | — | — | US | disclosed |
| WO-2010053825-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207717-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | HTR2A, HTR6, HTR5A | HTR2A 1/4885HTR2C 6/4885HTR2B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.