SCHEMBL7915002

SCHEMBL7915002

FC(F)(F)Sc1ccc(NC(=S)NC2=CC[CH]C=C2)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.41
CYP2C9 P11712 2/20 0.41
ALDH1A1 P00352 12/20 0.40
MAPT P10636 11/20 0.40
KMT2A Q03164 10/20 0.40
MEN1 O00255 9/20 0.40
NPSR1 Q6W5P4 3/20 0.40
HTT P42858 3/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
LMNA P02545 5/20 0.36
GAA P10253 3/20 0.34
IDO1 P14902 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C19 P33261 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALOX12 P18054 2/20 0.32
THRB P10828 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7911948 0.85 ALDH1A1 (0.40) ALDH1A1MAPTKMT2AMEN1NPSR1
SCHEMBL7166721 0.82 MAPT (0.51) ALDH1A1MAPTKMT2AMEN1NPSR1
SCHEMBL7163887 0.81 KMT2A (0.64) ALDH1A1MAPTKMT2AMEN1NPSR1
SCHEMBL7159183 0.79 ALDH1A1 (0.42) ALDH1A1MAPTKMT2AMEN1NPSR1
SCHEMBL7645141 0.79 ALDH1A1 (0.42) ALDH1A1MAPTKMT2AMEN1NPSR1
SCHEMBL7638965 0.79 ALDH1A1 (0.52) ALDH1A1MAPTKMT2AMEN1NPSR1
SCHEMBL7166469 0.79 MEN1 (0.51) CYP3A4CYP2C9ALDH1A1MAPTKMT2A
SCHEMBL7914993 0.78 ALDH1A1 (0.40) ALDH1A1MAPTKMT2AMEN1NPSR1
SCHEMBL7161939 0.77 ALDH1A1 (0.37) ALDH1A1MAPTKMT2AMEN1NPSR1
SCHEMBL6811919 0.76 MAPT (0.48) CYP3A4CYP2C9ALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207715-B1 USEFUL IN THERAPY OF DISEASES ASSOCIATED WITH HERPES VIRUSES INCLUDING HUMAN CYTOMEGALOVIRUS, HERPES SIMPLEX VIRUSES, EPSTEIN-BARR VIRUS, VARICELLA-ZOSTER VIRUS, HUMAN HERPESVIRUSES-6 AND -7, AND KAPOSI HERPES VIRUS AMERICAN HOME PRODUCTS CORPORATION 2001-03-27 US disclosed