Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914966 | 0.89 | PDE4D (0.41) | PDE4DKMT2AMEN1POLBLMNA | |
| SCHEMBL7914919 | 0.89 | PDE4D (0.53) | PDE4DKMT2AMEN1POLBRAB9A | |
| SCHEMBL7914704 | 0.89 | PDE4D (0.42) | PDE4DKMT2AMEN1POLBLMNA | |
| SCHEMBL3790847 | 0.88 | PDE4D (0.68) | PDE4DKMT2AMEN1POLBRAB9A | |
| SCHEMBL3785808 | 0.87 | PDE4D (0.52) | PDE4DKMT2AMEN1POLBRAB9A | |
| SCHEMBL7915385 | 0.87 | STK10 (0.39) | KMT2AMEN1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL4321191 | 0.86 | PDE4D (0.50) | PDE4DKMT2AMEN1POLBRAB9A | |
| SCHEMBL8067401 | 0.82 | ALDH1A1 (0.42) | PDE4DKMT2AMEN1POLBRAB9A | |
| SCHEMBL8057832 | 0.81 | PDE4D (0.49) | PDE4DKMT2AMEN1POLBNPSR1 | |
| SCHEMBL3467918 | 0.79 | ALDH1A1 (0.43) | PDE4DKMT2AMEN1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |