Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070659 | 0.89 | STK10 (0.38) | STK10SLKKMT2AMEN1MAPT | |
| SCHEMBL7916008 | 0.87 | PDE4D (0.52) | KMT2AMEN1MAPTSMN1; SMN2GAA | |
| SCHEMBL7914966 | 0.86 | PDE4D (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8057832 | 0.84 | PDE4D (0.49) | KMT2AMEN1MAPTGAAPDE4B | |
| SCHEMBL8067401 | 0.82 | ALDH1A1 (0.42) | KMT2AMEN1MAPTSMN1; SMN2GAA | |
| SCHEMBL8066904 | 0.80 | PDE4D (0.54) | STK10SLKKMT2AMEN1MAPT | |
| SCHEMBL16158918 | 0.78 | SMN1; SMN2 (0.40) | KMT2AMEN1MAPTSMN1; SMN2HTR1A | |
| SCHEMBL8071506 | 0.78 | PDE4B (0.48) | STK10SLKKMT2AMEN1MAPT | |
| SCHEMBL4326854 | 0.77 | PDE4D (0.48) | KMT2AMEN1MAPTSMN1; SMN2GAA | |
| SCHEMBL8066265 | 0.77 | HTR1A (0.46) | STK10SLKKMT2AMAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |