Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.65 |
| ▸ | RAB9A | P51151 | 10/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | TP53 | P04637 | 6/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30017278 | 0.89 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL21475214 | 0.89 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL13086314 | 0.84 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL11309004 | 0.84 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL14972591 | 0.84 | MEN1 (0.66) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL11573279 | 0.83 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| Hydrochloric Acid SCHEMBL16539303 | 0.82 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL23657657 | 0.82 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL7300937 | 0.82 | TRPV1 (0.60) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6814178 | 0.81 | KCNQ3 (0.60) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1178898-C | Process for preparing N- (3-amino-4-fluorophenyl) sulfonamides, N- (3-amino-4-fluorophenyl) carboxamides and N- (3-amino-4-fluorophenyl) carbamates | — | 2004-12-08 | — | — | CN | disclosed |
| US-6218565-B1 | 1-FLUORO-2,4-DIAMINO-BENZENE IS REACTED WITH SULPHONYL CHLORIDES, CARBONYL CHLORIDES OR CHLORORFORMIC ESTERS IN THE PRESENCE OF AN ACID ACCEPTOR AND IN THE PRESENCE OF A DILUENT | BAYER AKTIENGESELLSCHAFT (DE) | 2001-04-17 | — | — | US | disclosed |
| CN-1285816-A | Method for producing N-(3-amino-4-fluorophenyl)-sulphonamides, N-(3-amino-4-fluorophenyl) carboxylic acid amides and N-(3-amino-4-fluorophenyl) carbamates | BAYER AG (DE) | 2001-02-28 | — | — | CN | disclosed |