Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172656 | 0.83 | ATM (0.57) | ATMTACR1METAP2HPGDMC4R | |
| SCHEMBL7912865 | 0.80 | ATM (0.30) | ATM | |
| SCHEMBL7917175 | 0.78 | ATM (0.53) | ATMTACR1METAP2HPGDMC4R | |
| SCHEMBL2173199 | 0.77 | ATM (0.52) | ATMTACR1METAP2HPGDSMN1; SMN2 | |
| SCHEMBL2170887 | 0.77 | ATM (0.52) | ATMTACR1METAP2ALDH1A1SLC6A4 | |
| SCHEMBL7921565 | 0.74 | ALDH1A1 (0.51) | ATMTACR1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL7910450 | 0.73 | ATM (0.61) | ATMTACR1METAP2HPGDMC4R | |
| SCHEMBL7919481 | 0.73 | ATM (0.53) | ATMTACR1HPGDMC4RMMP8 | |
| SCHEMBL2170262 | 0.72 | CYP17A1 (0.52) | ATMHPGDSMN1; SMN2NR3C2MEN1 | |
| SCHEMBL3816356 | 0.72 | MC4R (0.50) | ATMTACR1METAP2HPGDMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054968-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-20 | — | — | WO | disclosed |