Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172656 | 0.83 | ATM (0.57) | ATMMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14804612 | 0.80 | ATM (0.51) | ATMMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4797150 | 0.79 | TACR1 (0.59) | TACR1 | |
| SCHEMBL21077981 | 0.79 | SMN1; SMN2 (0.51) | ATMMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7910450 | 0.79 | ATM (0.61) | ATMMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7917175 | 0.79 | ATM (0.53) | ATMALDH1A1SMN1; SMN2TACR1HPGD | |
| SCHEMBL2170887 | 0.78 | ATM (0.52) | ATMMEN1KMT2AALDH1A1TACR1 | |
| SCHEMBL2173199 | 0.78 | ATM (0.52) | ATMMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7921565 | 0.78 | ALDH1A1 (0.51) | ATMMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3816356 | 0.77 | MC4R (0.50) | ATMMEN1KMT2ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054968-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-20 | — | — | WO | disclosed |