Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30771660 | 0.84 | GPR84 (0.62) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL30771661 | 0.84 | GPR84 (0.62) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL1253068 | 0.84 | GPR84 (0.62) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL19410688 | 0.80 | GPR84 (0.61) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL4666383 | 0.79 | GPR84 (0.60) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11171165 | 0.79 | VDR (0.58) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| Vibrindole A SCHEMBL5960513 | 0.79 | GPR84 (0.71) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL30626309 | 0.79 | GPR84 (0.71) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL255420 | 0.79 | GPR84 (0.71) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL2548826 | 0.77 | GPR84 (0.54) | GPR84FFAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225352-B1 | USEFUL AS AGENTS IN THE TREATMENT OF CANCER, ALZHEIMERS DISEASE, THROMBOSIS, INFLAMMATORY DISEASES, AND BACTERIAL RESISTANCE | WARNER-LAMBERT COMPANY | 2001-05-01 | — | — | US | claimed |
| EP-1401449-B1 | TETRACYCLIC COMPOUNDS AS PDE5-INHIBITORS | LILLY ICOS LLC (US) | 2007-04-25 | — | — | EP | disclosed |
| US-6225352-B1 | USEFUL AS AGENTS IN THE TREATMENT OF CANCER, ALZHEIMERS DISEASE, THROMBOSIS, INFLAMMATORY DISEASES, AND BACTERIAL RESISTANCE | WARNER-LAMBERT COMPANY | 2001-05-01 | — | — | US | disclosed |