Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22661900 | 1.00 | GRM6 (0.37) | GRM6OPRM1OPRL1CYP2C19BRD4 | |
| SCHEMBL22661873 | 1.00 | GRM6 (0.37) | GRM6OPRM1OPRL1CYP2C19BRD4 | |
| SCHEMBL2491207 | 0.86 | GRM6 (0.40) | GRM6CYP2C19SIGMAR1 | |
| SCHEMBL1508976 | 0.82 | MAPT (0.43) | GRM6OPRM1OPRL1MAPTSIGMAR1 | |
| SCHEMBL1508882 | 0.82 | MAPT (0.43) | GRM6OPRM1OPRL1MAPTSIGMAR1 | |
| SCHEMBL2486957 | 0.82 | MAPT (0.43) | GRM6OPRM1OPRL1MAPTSIGMAR1 | |
| SCHEMBL2489070 | 0.82 | CYP2C19 (0.35) | GRM6OPRM1OPRL1CYP2C19MAPT | |
| SCHEMBL2492327 | 0.78 | TOP2A (0.33) | GRM6OPRM1OPRL1CYP2C19SIGMAR1 | |
| SCHEMBL23040022 | 0.74 | SIGMAR1 (0.52) | MAPTSIGMAR1 | |
| SCHEMBL23040051 | 0.74 | MAPT (0.40) | CYP2C19BRD4MAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |
| US-11370800-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2022-06-28 | — | — | US | disclosed |
| EP-3580205-B1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272 | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2021-05-05 | — | — | EP | disclosed |
| US-20200377521-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272 | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-12-03 | — | — | US | disclosed |
| US-10836778-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2020-11-17 | — | — | US | disclosed |
| WO-2010082612-A1 | IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE | 第一三共株式会社 (JP) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10836778-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | DHPS, DUS2, RPS2 | GRM6 3690/4885OPRM1 2322/4885OPRL1 1692/4885 |
| US-11370800-B2 | Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272 | DHPS, DUS2, RPS2 | GRM6 3690/4885OPRM1 2322/4885OPRL1 1692/4885 |
| US-20200377521-A1 | PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272 | DHPS, DUS2, RPS2 | GRM6 3690/4885OPRM1 2322/4885OPRL1 1692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.