Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16867095 | 0.83 | ALDH1A1 (0.48) | PPARGTSHRALDH1A1KMT2AMAPT | |
| Bromide SCHEMBL11028063 | 0.82 | POLB (0.45) | PPARGTSHRALDH1A1KMT2AMAPT | |
| SCHEMBL7477852 | 0.82 | TSHR (0.54) | PPARGTSHRALDH1A1MAPK1KMT2A | |
| SCHEMBL14821764 | 0.81 | POLB (0.46) | PPARGALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL22074459 | 0.79 | POLB (0.47) | PPARGALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL16870810 | 0.77 | PPARG (0.48) | PPARGALDH1A1KMT2AMAPTLMNA | |
| Bromide SCHEMBL3576414 | 0.76 | KDM4E (0.50) | TSHRALDH1A1MAPTHSD17B10LMNA | |
| SCHEMBL3576418 | 0.74 | KDM4E (0.51) | TSHRALDH1A1MAPTHSD17B10LMNA | |
| SCHEMBL11160441 | 0.71 | ALDH1A1 (0.47) | PPARGTSHRALDH1A1MAPK1KMT2A | |
| SCHEMBL3044303 | 0.70 | LPAR1 (0.36) | TSHRALDH1A1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214801-B1 | INHIBITION OF DNA OR RNA VIRAL PROLIFERATION | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2001-04-10 | — | — | US | disclosed |
| WO-1997027205-A1 | IMIDAZO[1,2-A]PYRIDINE C-NUCLEOSIDES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1997-07-31 | — | — | WO | disclosed |